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Article

Phenotype vs genotype in the evolution of astrocytic brain tumors.

Toxicologic pathology - 1 Jan 2000

Kleihues P, Ohgaki H

Abstract excerpt

Astrocytic brain tumors are the most frequent human gliomas and they include a wide range of neoplasms with distinct clinical, histopathologic, and genetic features. Diffuse astrocytomas are predominantly located in the cerebral hemispheres of adults and have an inherent tendency to progress to anaplastic astrocytoma and (secondary) glioblastoma. The majority of glioblastomas develop de novo (primary...

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Source

Identifiers

PMID: 10669004
DOI: 10.1177/019262330002800121

Genes

EGFR
MDM2
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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