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Cytogenetic and molecular genetic analyses of giant cell glioblastoma multiforme reveal distinct profiles in giant cell and non-giant cell subpopulations.

Cancer genetics and cytogenetics - 1 May 2007

Martinez Ramon, Roggendorf Wolfgang, Baretton Gustavo, Klein Rüdiger, Toedt Grisha, Lichter Peter, Schackert Gabriele, Joos Stefan

Abstract excerpt

We have comparatively analyzed mechanisms associated with chromosomal and microsatellite instability in giant cell glioblastoma multiforme (gcGBM) and classic GBM. This included microsatellite instability (MSI), loss of expression of four major mismatch repair (MMR) proteins, aberrations of five chromosomes, EGFR copy number, and TP53 mutations. MSI was more frequent among gcGBM (30 vs. 7.8%, P = 0.054). TP53...

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PMID: 17498554
DOI: 10.1016/j.cancergencyto.2007.01.006

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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