Article
Genetic Alterations in Gliosarcoma and Giant Cell Glioblastoma.
Brain pathology (Zurich, Switzerland) - 1 Jul 2016
Oh Ji Eun, Ohta Takashi, Nonoguchi Naosuke, Satomi Kaishi, Capper David, Pierscianek Daniela, Sure Ulrich, Vital Anne, Paulus Werner, Mittelbronn Michel, Antonelli Manila, Kleihues Paul, Giangaspero Felice, Ohgaki Hiroko
Abstract excerpt
The majority of glioblastomas develop rapidly with a short clinical history (primary glioblastoma IDH wild-type), whereas secondary glioblastomas progress from diffuse astrocytoma or anaplastic astrocytoma. IDH mutations are the genetic hallmark of secondary glioblastomas. Gliosarcomas and giant cell glioblastomas are rare histological glioblastoma variants, which usually develop rapidly. We determined the...
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