Article

Pseudo-mutant p53 as a targetable phenotype of <i>DNMT3A</i> -mutated pre-leukemia

2021-05-30

Abstract excerpt

Pre-leukemic clones carrying DNMT3A mutations have a selective advantage and an inherent chemo-resistance, however the basis for this phenotype has not been fully elucidated. Mutations affecting the gene TP53 occur in pre-leukemic hematopoietic stem/progenitor cells (preL-HSPCs) and lead to chemo-resistance. Many of these mutations cause a conformational change and some of them were shown to enhance self-renewa...

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Literature Corpus work: b8e650ab-d05c-5adf-9969-1d61891c2cd9
DOI: 10.1101/2021.05.30.446347

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