Article
Pseudo-mutant P53 is a unique phenotype of DNMT3A-mutated pre-leukemia.
Haematologica - 1 Nov 2022
Tuval Amos, Brilon Yardena, Azogy Hadas, Moskovitz Yoni, Leshkowitz Dena, Salame Tomer M, Minden Mark D, Tal Perry, Rotter Varda, Oren Moshe, Kaushansky Nathali, Shlush Liran I
Abstract excerpt
Pre-leukemic clones carrying DNMT3A mutations have a selective advantage and an inherent chemoresistance, however the basis for this phenotype has not been fully elucidated. Mutations affecting the gene TP53 occur in pre-leukemic hematopoietic stem/progenitor cells (preL-HSPC) and lead to chemoresistance. Many of these mutations cause a conformational change and some of them were shown to enhance self-renewal...
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