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Article

Lymphotoxin signalling in immune homeostasis and the control of microorganisms.

Nature reviews. Immunology - 1 Apr 2013

Upadhyay Vaibhav, Fu Yang-Xin

Abstract excerpt

Lymphotoxin (LT) is a member of the tumour necrosis factor (TNF) superfamily that was originally thought to be functionally redundant to TNF, but these proteins were later found to have independent roles in driving lymphoid organogenesis. More recently, LT-mediated signalling has been shown to actively contribute to effector immune responses. LT regulates dendritic cell and CD4(+) T cell homeostasis in the steady...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23524463
DOI: 10.1038/nri3406
PMCID: PMC3900493

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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