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Tumor Necrosis Factor Alpha Signaling and Organogenesis

30 Jul 2021

Abstract excerpt

Tumor necrosis factor alpha (TNF-α) plays important roles in processes such as immunomodulation, fever, inflammatory response, inhibition of tumor formation, and inhibition of viral replication. TNF-α and its receptors are ubiquitously expressed in developing organs and they regulate the survival, proliferation, and apoptosis of embryonic stem cells (ESCs) and progenitor cells. TNF-α is an important inflammatory...

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PMID: 34395451
DOI: 10.3389/fcell.2021.727075

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