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Article

Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation.

Proceedings of the National Academy of Sciences of the United States of America - 13 Jun 2006

Cui Chang-Yi, Hashimoto Tsuyoshi, Grivennikov Sergei I, Piao Yulan, Nedospasov Sergei A, Schlessinger David

Abstract excerpt

Mutations in the EDA gene cause anhidrotic/hypohidrotic ectodermal dysplasia, a disorder characterized by defective formation of hair, sweat glands, and teeth in humans and in a mouse model, "Tabby" (Ta). The gene encodes ectodysplasin, a TNF ligand family member that activates the NF-kappaB-signaling pathway, but downstream targets and the mechanism of skin appendage formation have been only partially analyzed....

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Source

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Identifiers

PMID: 16738056
DOI: 10.1073/pnas.0509678103
PMCID: PMC1482580

Genes

EDA
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation.PMID 16738056Read ↗

Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar.Semantic proximity Read ↗

Ectodysplasin-A1 is sufficient to rescue both hair growth and sweat glands in Tabby miceSemantic proximity Read ↗

Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair folliclesSemantic proximity Read ↗

Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle developmentSemantic proximity Read ↗

Molecular aspects of hypohidrotic ectodermal dysplasia.Semantic proximity Read ↗

Ectodysplasin signaling in development.Semantic proximity Read ↗

The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains.Semantic proximity Read ↗

Involvement of a novel Tnf receptor homologue in hair follicle induction.Semantic proximity Read ↗

Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices.Semantic proximity Read ↗

Ectodysplasin receptor-mediated signaling is essential for embryonic submandibular salivary gland development.Semantic proximity Read ↗

Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A.Semantic proximity Read ↗

Candidate EDA targets revealed by expression profiling of primary keratinocytes from Tabby mutant mice.Semantic proximity Read ↗

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