Article
The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissues.
The Journal of experimental medicine - 6 Sept 1999
Wu Q, Wang Y, Wang J, Hedgeman E O, Browning J L, Fu Y X
Abstract excerpt
Although several cytokines, including tumor necrosis factor (TNF), can promote the growth of dendritic cells (DCs) in vitro, the cytokines that naturally regulate DC development and function in vivo have not been well defined. Here, we report that membrane lymphotoxin (LT), instead of TNF, regulates the migration of DCs in the spleen. LTalpha(-/-) mice, lacking membrane LTalpha/beta and LTalpha(3), show markedly...
Topics
- Animals
- Bone Marrow Cells
- Cell Count
- Cell Movement
- Dendritic Cells
- Female
- Lymphocyte Culture Test, Mixed
- Lymphoid Tissue
- Lymphotoxin beta Receptor
- Lymphotoxin-alpha
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout