Article
Tiam1 mutations in human renal-cell carcinomas.
International journal of cancer - 1 Nov 2000
Engers R, Zwaka T P, Gohr L, Weber A, Gerharz C D, Gabbert H E
Abstract excerpt
Tiam1 activates the Rho-like GTPase Rac1, and studies indicate that Tiam1-Rac1 signaling affects invasion in different ways depending on the cell type studied. However, no investigations on Tiam1 in human tumors have been reported. Here, we show that for 4 of 5 human renal-cell carcinoma (RCC) cell lines the expression levels of Tiam1 tended to be inversely correlated with in vitro invasiveness, whereas no...
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