Article
HLA genotyping is useful in the evaluation of the risk for coeliac disease in the 1st-degree relatives of patients with coeliac disease.
Scandinavian journal of gastroenterology - 1 Nov 2006
Karinen Hannele, Kärkkäinen Päivi, Pihlajamäki Jussi, Janatuinen Esko, Heikkinen Markku, Julkunen Risto, Kosma Veli-Matti, Naukkarinen Anita, Laakso Markku
Abstract excerpt
OBJECTIVE: Coeliac disease (CD) is a common disease with a strong heredity. About 10-20% of 1st-degree relatives of probands develop CD. Relatives should be screened for CD, because if not treated, CD exposes patients to numerous complications. The heterogeneity of symptoms and the lifetime-spanning risk of CD render the timing of CD antibody and/or gastroscopy screenings difficult. As CD susceptibility has been...
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