Article
Development of a genetic sensor that eliminates p53 deficient cells.
Nature communications - 13 Nov 2017
Mircetic Jovan, Dietrich Antje, Paszkowski-Rogacz Maciej, Krause Mechthild, Buchholz Frank
Abstract excerpt
The TP53 gene fulfills a central role in protecting cells from genetic insult. Given this crucial role it might be surprising that p53 itself is not essential for cell survival. Indeed, TP53 is the single most mutated gene across different cancer types. Thus, both a theoretical and a question of significant practical applicability arise: can cells be programmed to make TP53 an essential gene? Here we present a...
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