Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of stability on the biological function of p53.

The Journal of biological chemistry - 6 Nov 2009

Khoo Kian Hoe, Mayer Sebastian, Fersht Alan R

Abstract excerpt

The core domain of the tumor suppressor p53 has low thermodynamic stability, and many oncogenic mutations cause it to denature rapidly at body temperature. We made a series of core domain mutants that are significantly less or more stable than wild type to investigate effects of stability on the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Cell Survival
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Stability

Share to Protein Structure, Tertiary

Share to Transcription, Genetic

Share to Transcriptional Activation

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 19700401
DOI: 10.1074/jbc.M109.033183
PMCID: PMC2781498

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19700401-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of stability on the biological function of p53.PMID 19700401Read ↗

Thermodynamic stability of wild-type and mutant p53 core domain.Semantic proximity Read ↗

Mechanisms of mutant p53 stabilization in cancer.Semantic proximity Read ↗

Structural and functional implications of p53 missense cancer mutationsSemantic proximity Read ↗

Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stabilitySemantic proximity Read ↗

A split-ubiquitin-based assay detects the influence of mutations on the conformational stability of the p53 DNA binding domain in vivo.Semantic proximity Read ↗

Small molecule induced reactivation of mutant p53 in cancer cells.Semantic proximity Read ↗

Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy.Semantic proximity Read ↗

Characterization of sequence elements involved in p53 stability regulation reveals cell type dependence for p53 degradation.Semantic proximity Read ↗

Genome Stability Requires p53.Semantic proximity Read ↗

Mutant p53 accumulation in human breast cancer is not an intrinsic property or dependent on structural or functional disruption but is regulated by exogenous stress and receptor status.Semantic proximity Read ↗

Cancer-associated p53 tetramerization domain mutants: quantitative analysis reveals a low threshold for tumor suppressor inactivation.Semantic proximity Read ↗

Loss of function and p53 protein stabilization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.