Article
Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor.
The EMBO journal - 17 Nov 1997
Gether U, Lin S, Ghanouni P, Ballesteros J A, Weinstein H, Kobilka B K
Abstract excerpt
Agonist binding to G protein-coupled receptors is believed to promote a conformational change that leads to the formation of the active receptor state. However, the character of this conformational change which provides the important link between agonist binding and G protein coupling is not known. Here we report evidence that agonist binding to the beta2 adrenoceptor induces a conformational change around 125Cys...
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