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Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactin

1 Dec 1997

Abstract excerpt

Huntington's disease (HD) is an inherited neurodegenerative disease caused by expansion of a polyglutamine repeat in the HD protein huntingtin. Huntingtin's localization within the cell includes an association with cytoskeletal elements and vesicles. We previously identified a protein (HAP1) which binds to huntingtin in a glutamine repeat length-dependent manner. We now report that HAP1 interacts with...

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Genetic Neurodegenerative Diseases
Mitochondrial Function and Pathology
Neurological disorders and treatments

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9361024
DOI: 10.1093/hmg/6.13.2205

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Huntingtin-associated protein 1 (HAP1) interacts with the p150Glued subunit of dynactinPMID 9361024Read ↗

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A Human HAP1 HomologueSemantic proximity Read ↗

HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.Semantic proximity Read ↗

PACSIN 1 interacts with huntingtin and is absent from synaptic varicosities in presymptomatic Huntington's disease brainsSemantic proximity Read ↗

Hypothesis: huntingtin may function in membrane association and vesicular traffickingThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Membrane Proteins in Health and Disease.Semantic proximity Read ↗

Interaction of tau protein with the dynactin complex.Semantic proximity Read ↗

Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor.Semantic proximity Read ↗

Cytoplasmic dynein intermediate chain phosphorylation regulates binding to dynactin.Semantic proximity Read ↗

Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity.Semantic proximity Read ↗

Dynactin p150Glued–Deficiency in Midbrain Dopaminergic Neurons Leads to Progressive Neurodegeneration and Endoplasmic Reticulum DysfunctionSemantic proximity Read ↗

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