Article

Dynactin p150Glued–Deficiency in Midbrain Dopaminergic Neurons Leads to Progressive Neurodegeneration and Endoplasmic Reticulum Dysfunction

2022-02-08

Abstract excerpt

<title>Abstract</title> <p>Background Multiple missense mutations in <italic>DCTN1</italic> gene have been linked to Perry syndrome (PS), a rare neurodegenerative disease clinically manifested with parkinsonism, mental depression, and central hypoventilation. <italic>DCTN1</italic> encodes dynactin p150<sup>Glued</sup> protein, the largest subunit of dynactin motor protein complex. The PS-related mutations are c...

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Literature Corpus work: 7368fd10-dec5-5804-8431-e8f23a6f0e0d
DOI: 10.21203/rs.3.rs-1324919/v1

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