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Article

Interaction of tau protein with the dynactin complex.

The EMBO journal - 31 Oct 2007

Magnani Enrico, Fan Juan, Gasparini Laura, Golding Matthew, Williams Meredith, Schiavo Giampietro, Goedert Michel, Amos Linda A, Spillantini Maria Grazia

Abstract excerpt

Tau is an axonal microtubule-associated protein involved in microtubule assembly and stabilization. Mutations in Tau cause frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17), and tau aggregates are present in Alzheimer's disease and other tauopathies. The mechanisms leading from tau dysfunction to neurodegeneration are still debated. The dynein-activator complex dynactin has an essential...

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Identifiers

PMID: 17932487
DOI: 10.1038/sj.emboj.7601878
PMCID: PMC2063488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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