Article
Evidence for clonal deletion and clonal anergy after intrathymic antigen injection in a transplantation model.
Transplantation - 27 Oct 1997
Gillanders W E, Arima T, Tu F, Hansen T H, Flye M W
Abstract excerpt
Intrathymic (IT) antigen injection has been shown to induce antigen-specific systemic tolerance in the rodent. To delineate the mechanisms responsible for the induction of tolerance, we used the 2C line of T cell receptor transgenic mice. The majority of T cells in 2C mice express an antigen rece...
Topics
- Adoptive Transfer
- Animals
- Antilymphocyte Serum
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Clonal Anergy
- Clonal Deletion
- Epitopes
- Graft Survival
- Immune Tolerance
- Injections, Intralymphatic
- Injections, Intraperitoneal
- Lymphocyte Activation
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Transgenic