Article
Evidence for clonal deletion and clonal anergy after intrathymic antigen injection in a transplantation model.
Transplantation - 27 Oct 1997
Gillanders W E, Arima T, Tu F, Hansen T H, Flye M W
Abstract excerpt
Intrathymic (IT) antigen injection has been shown to induce antigen-specific systemic tolerance in the rodent. To delineate the mechanisms responsible for the induction of tolerance, we used the 2C line of T cell receptor transgenic mice. The majority of T cells in 2C mice express an antigen receptor specific for the major histocompatibility complex class I alloantigen Ld and can be identified with the clonotypic...
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