Article
Genetic characterization of strain differences in the ability to mediate CD40/CD28-independent rejection of skin allografts.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2000
Williams M A, Trambley J, Ha J, Adams A B, Durham M M, Rees P, Cowan S R, Pearson T C, Larsen C P
Abstract excerpt
Simultaneous blockade of the CD40 and CD28 T cell costimulatory pathways effectively promotes skin allograft survival in C3H/HeJ mice, extending median survival times (MSTs) beyond 100 days. This strategy is markedly less effective in C57BL/6 mice, with MSTs ranging between 20 and 30 days. In this study, we investigate the underlying genetic causes of these distinct phenotypes. Using H-2 congenic mice, we show...
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