Article
Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo.
Science (New York, N.Y.) - 21 Dec 1990
Murphy K M, Heimberger A B, Loh D Y
Abstract excerpt
In order to examine the mechanisms by which clonal deletion of autoreactive T cells occurs, a peptide antigen was used to induce deletion of antigen-reactive thymocytes in vivo. Mice transgenic for a T cell receptor (TCR) that reacts to this peptide contain thymocytes that progress from the immat...
Topics
- Amino Acid Sequence
- Animals
- Antigens, Differentiation, T-Lymphocyte
- CD4 Antigens
- CD8 Antigens
- Mice
- Mice, Transgenic
- Microscopy, Electron
- Molecular Sequence Data
- Ovalbumin
- Phagocytosis
- Phenotype