Article
Nonmitogenic anti-CD3F(ab')2 fragments inhibit lethal murine graft-versus-host disease induced across the major histocompatibility barrier.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 1993
Blazar B R, Taylor P A, Snover D C, Bluestone J A, Vallera D A
Abstract excerpt
We have investigated the in vivo administration of nonmitogenic anti-CD3F(ab')2 fragments for the prevention of lethal graft-vs-host disease (GVHD) in irradiated recipients of fully allogeneic bone marrow cells plus splenocyte (BMS) inocula. Recipients of anti-CD3F(ab')2 fragments administered fo...
Topics
- Animals
- Bone Marrow Transplantation
- CD3 Complex
- Female
- Graft vs Host Disease
- Immunoglobulin Fab Fragments
- Immunosuppressive Agents
- Major Histocompatibility Complex
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mitogens
- Phenotype
- Spleen
- Thymus Gland
- Transplantation, Homologous