Article
Frequency and clinical correlates of somatic Ying Yang 1 mutations in sporadic insulinomas.
The Journal of clinical endocrinology and metabolism - 1 May 2015
Lichtenauer Urs D, Di Dalmazi Guido, Slater Emily P, Wieland Thomas, Kuebart Anne, Schmittfull Anett, Schwarzmayr Thomas, Diener Susanne, Wiese Dominik, Thasler Wolfgang E, Reincke Martin, Meitinger Thomas, Schott Matthias, Fassnacht Martin, Bartsch Detlef K, Strom Tim M, Beuschlein Felix
Abstract excerpt
CONTEXT: Insulinomas represent pancreatic neuroendocrine neoplasms that cause severe morbidity attributed to their often pronounced endocrine activity. Apart from hereditary forms such as multiple endocrine neoplasia type 1 (MEN-1), genetic causes for sporadic insulinoma development had remained obscure until recently. Applying next-generation sequencing methods, disease-causing genetic alterations have been...
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