Article
Multiple endocrine neoplasia type 1 gene mutations in sporadic gastrinomas in Japan.
Oncology reports - 1 Jul 2005
Kawamura Junichiro, Shimada Yutaka, Komoto Izumi, Okamoto Hiroomi, Itami Atsushi, Doi Ryuichiro, Fujimoto Koji, Kosugi Shinji, Imamura Masayuki
Abstract excerpt
The molecular mechanisms responsible for the development and/or progression of gastrinomas are largely unknown. Studies involving sporadic enteropancreatic neuro-endocrine tumors suggest that mutations in the MEN1 gene occur in some tumors and probably play an important role in their pathogenesis. In this study, we examined whether somatic mutations in the MEN1 gene are also responsible for sporadic gastrinomas...
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