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Article

Identification of MEN1 mutations in sporadic enteropancreatic neuroendocrine tumors by analysis of paraffin-embedded tissue.

Clinical chemistry - 1 Jan 1999

Mailman M D, Muscarella P, Schirmer W J, Ellison E C, O'Dorisio T M, Prior T W

Abstract excerpt

Gastrinomas and other gastrointestinal neuroendocrine tumors may occur sporadically or as part of the inherited syndrome multiple endocrine neoplasia type 1 (MEN1). Mutations in the recently identified MEN1 gene have been described in sporadic gastrinomas and insulinomas. This study describes tec...

Topics

DNA, Neoplasm
Duodenal Neoplasms
Gastrinoma
Gastrointestinal Neoplasms
Heterozygote
Humans
Insulinoma
Liver Neoplasms
Multiple Endocrine Neoplasia Type 1
Mutation
Neoplasm Proteins
Neuroendocrine Tumors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pancreatic Neoplasms

Paraffin Embedding

Proto-Oncogene Proteins

Stomach Neoplasms

Source

Identifiers

PMID: 9895334

Genes

MEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9895334-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Identification of MEN1 mutations in sporadic enteropancreatic neuroendocrine tumors by analysis of paraffin-embedded tissue.PMID 9895334Read ↗

Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas.Semantic proximity Read ↗

Multiple endocrine neoplasia type 1 gene mutations in sporadic gastrinomas in Japan.Semantic proximity Read ↗

Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine tumors and not restricted to foregut neoplasms.Semantic proximity Read ↗

Deletion of chromosome 1, but not mutation of MEN-1, predicts prognosis in sporadic pancreatic endocrine tumors.Semantic proximity Read ↗

Screening of the Men1 gene and discovery of germ-line and somatic mutations in apparently sporadic parathyroid tumors.Semantic proximity Read ↗

Allelic deletions on chromosome 11q13 in multiple endocrine neoplasia type 1-associated and sporadic gastrinomas and pancreatic endocrine tumors.Semantic proximity Read ↗

Genotype/phenotype correlation of multiple endocrine neoplasia type 1 gene mutations in sporadic gastrinomas.Semantic proximity Read ↗

MENIN loss as a tissue-specific driver of tumorigenesis.Semantic proximity Read ↗

Identification and characterization of the multiple endocrine neoplasia type 1 (MEN1) gene.Semantic proximity Read ↗

MEN1 mutation analysis in Chinese patients with multiple endocrine neoplasia type 1.Semantic proximity Read ↗

Natural History of MEN1 GEP-NET: Single-Center Experience After a Long Follow-Up.Semantic proximity Read ↗

MEN1 in pancreatic endocrine tumors: analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of cases.Semantic proximity Read ↗

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