Arginine 357 of SecY is needed for SecA-dependent initiation of preprotein translocation.

doi:10.1016/j.febslet.2007.03.081

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Article

Arginine 357 of SecY is needed for SecA-dependent initiation of preprotein translocation.

FEBS letters - 1 May 2007

de Keyzer Jeanine, Regeling Anouk, Driessen Arnold J M

Abstract excerpt

The Escherichia coli SecYEG complex forms a transmembrane channel for both protein export and membrane protein insertion. Secretory proteins and large periplasmic domains of membrane proteins require for translocation in addition the SecA ATPase. The conserved arginine 357 of SecY is essential for a yet unidentified step in the SecA catalytic cycle. To further dissect its role, we have analysed the requirement...

Topics

Adenosine Triphosphatases
Amino Acid Substitution
Arginine
Bacterial Proteins
Cell Membrane
Escherichia coli Proteins
Membrane Proteins
Membrane Transport Proteins
Mutation
Protein Precursors
Protein Transport
SEC Translocation Channels
SecA Proteins

Source

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Identifiers

PMID: 17433305
DOI: 10.1016/j.febslet.2007.03.081

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