Article
Arginine 357 of SecY is needed for SecA-dependent initiation of preprotein translocation.
FEBS letters - 1 May 2007
de Keyzer Jeanine, Regeling Anouk, Driessen Arnold J M
Abstract excerpt
The Escherichia coli SecYEG complex forms a transmembrane channel for both protein export and membrane protein insertion. Secretory proteins and large periplasmic domains of membrane proteins require for translocation in addition the SecA ATPase. The conserved arginine 357 of SecY is essential for a yet unidentified step in the SecA catalytic cycle. To further dissect its role, we have analysed the requirement...
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