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Article

Roles of SecG in ATP- and SecA-dependent protein translocation.

Proceedings of the National Academy of Sciences of the United States of America - 10 Nov 1998

Matsumoto G, Mori H, Ito K

Abstract excerpt

SecA, the translocation ATPase in Escherichia coli, undergoes cycles of conformational changes (insertion/deinsertion) in response to ATP and a preprotein. The membrane-embedded portion of protein translocase, SecYEG, has crucial roles in the SecA-driven preprotein translocation reaction. We previously identified a secY mutation (secY205) that did not allow an ATP- and preprotein-dependent (productive) insertion...

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Identifiers

PMID: 9811840
DOI: 10.1073/pnas.95.23.13567
PMCID: PMC24859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Roles of SecG in ATP- and SecA-dependent protein translocation.PMID 9811840Read ↗

SecY and SecA interact to allow SecA insertion and protein translocation across the Escherichia coli plasma membrane.Semantic proximity Read ↗

Protein translocation functions of Escherichia coli SecY: in vitro characterization of cold-sensitive secY mutants.Semantic proximity Read ↗

Multiple SecA molecules drive protein translocation across a single translocon with SecG inversion.Semantic proximity Read ↗

Characterization of a mutant form of SecA that alleviates a SecY defect at low temperature and shows a synthetic defect with SecY alteration at high temperature.Semantic proximity Read ↗

Genetic dissection of SecA: suppressor mutations against the secY205 translocase defect.Semantic proximity Read ↗

A SecE mutation that modulates SecY-SecE translocase assembly, identified as a specific suppressor of SecY defects.Semantic proximity Read ↗

Characterization of cold-sensitive secY mutants of Escherichia coli.Semantic proximity Read ↗

Superactive SecY variants that fulfill the essential translocation function with a reduced cellular quantity.Semantic proximity Read ↗

SecA membrane cycling at SecYEG is driven by distinct ATP binding and hydrolysis events and is regulated by SecD and SecF.Semantic proximity Read ↗

A large conformational change couples the ATP binding site of SecA to the SecY protein channel.Semantic proximity Read ↗

Translocation of proteins through the Sec61 and SecYEG channels.Semantic proximity Read ↗

Dimeric SecA is essential for protein translocation.Semantic proximity Read ↗

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