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Article

Expression of the<i>GLI2</i>oncogene and its isoforms in human basal cell carcinoma

1 May 2003

Abstract excerpt

BACKGROUND: Mutations of the patched (Ptc) gene, a developmental regulator implicated in the signalling pathway via sonic hedgehog (Shh) and smoothened (Smo), play an essential pathogenic role in the development of basal cell carcinomas (BCCs). We previously reported the upregulation of Shh signal transducers, including Ptc, Smo and hedgehog-interacting protein, in BCCs. In vertebrates, specific downstream...

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PMID: 12786818
DOI: 10.1046/j.1365-2133.2003.05284.x

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