Article

Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

2000-03-21

Abstract excerpt

Basal cell carcinoma is the most prevalent cancer in the western world, showing a rapid increase in incidence. Activation of the Sonic hedgehog/Patched (PTCH) signaling pathway because of PTCH1 inactivation is a key event in sporadic and familial basal cell carcinoma development in humans and is associated with transcriptional activation of specific target genes, including PTCH1 itself. These changes are analogous...

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Literature Corpus work: 4a1151fd-5857-5fc3-a8a6-026a92d587c3
DOI: 10.1073/pnas.97.7.3438

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