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Article

Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

21 Mar 2000

Abstract excerpt

Basal cell carcinoma is the most prevalent cancer in the western world, showing a rapid increase in incidence. Activation of the Sonic hedgehog/Patched (PTCH) signaling pathway because of PTCH1 inactivation is a key event in sporadic and familial basal cell carcinoma development in humans and is associated with transcriptional activation of specific target genes, including PTCH1 itself. These changes are...

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PMID: 10725363
DOI: 10.1073/pnas.050467397

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