Article
Interactive effect of the p53 gene and cigarette smoking on coronary artery disease.
Cardiovascular research - 1 Aug 1997
Wang X L, Wang J, Wilcken D E
Abstract excerpt
OBJECTIVE: p53 is a tumour suppressor protein involved in the control of cell growth and has an established role in carcinogenesis, particularly in relation to smoking. It may also be related to arteriosclerosis by affecting smooth muscle cell proliferation, a feature of atherogenesis. METHODS: We explored a role for p53 in atherogenesis by assessing the association between two DNA polymorphisms of the p53 gene...
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