The Arg72 variant of the p53 functional polymorphism (rs1042522) is associated with coronary artery disease in young South Africans of Indian ancestry.

doi:10.1016/j.gene.2016.07.040

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The Arg72 variant of the p53 functional polymorphism (rs1042522) is associated with coronary artery disease in young South Africans of Indian ancestry.

Gene - 30 Nov 2016

Khan Sajidah, Phulukdaree Alisa, Ramkaran Prithiksha, Moodley Devapregasan, Chuturgoon Anil A

Abstract excerpt

BACKGROUND AND AIM: Tumor protein p53 (p53), classically referred to as a tumor suppressor gene, is involved in cell cycle regulation and may be related to atherosclerosis by affecting smooth muscle cell proliferation, a feature of atherogenesis. A polymorphism at codon 72 (rs1042522) results in functional variability and hence plays a role in the pathophysiology of coronary artery disease (CAD). This...

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PMID: 27436625
DOI: 10.1016/j.gene.2016.07.040

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