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Article

Combined "pro-atherosclerotic" variants of the ACE and APOE genes increase the risk of the coronary artery disease associated with the presence of cigarette smoking.

Acta cardiologica - 1 Dec 2008

Zak Iwona, Niemiec Pawel, Balcerzyk Anna, Krauze Jolanta

Abstract excerpt

OBJECTIVE: Cigarette smoking increases the synthesis of angiotensin-1 converting enzyme (ACE) and induces oxidative modifications of the apolipoprotein E (apo E).Thus we explored the gene-environment interactions between APOE gene epsilon and ACE gene insertion/deletion polymorphisms and cigarette smoking in coronary artery disease (CAD) patients. METHODS: We analysed 360 subjects: 171 CAD patients and 189 blood...

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Share to Apolipoproteins E
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Peptidyl-Dipeptidase A

Share to Polymorphism, Genetic

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Source

Identifiers

PMID: 19157170
DOI: 10.2143/AC.63.6.2033392

Genes

ACE
APOE
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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