Article
Smoking-dependent and haplotype-specific effects of endothelial nitric oxide synthase gene polymorphisms on angiographically assessed coronary artery disease in Caucasian- and African-Brazilians.
Atherosclerosis - 1 Jul 2007
Rios Domingos L S, D'Onofrio Lorenza O, Souza Joares K, Queiroz Amália M, Raduy-Maron Luciana, Silva-Neto Naila, Carvalho Heitor G, Santos-Filho Ademar, Galvão-Castro Bernardo
Abstract excerpt
The nitric oxide produced by endothelial nitric oxide synthase (eNOS) plays a pivotal role in protecting the arterial wall from damages and atherosclerosis. The T-786C, the 27-bp repeat in intron 4, and the E298D eNOS gene polymorphisms were studied in 715 Brazilian patients (447 Caucasian- and 268 African-Brazilians) who underwent coronary angiography. The -786C frequency was increased in coronary artery disease...
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