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Article

Critical role of TrkB and brain-derived neurotrophic factor in the differentiation and survival of retinal pigment epithelium.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Nov 1997

Liu Z Z, Zhu L Q, Eide F F

Abstract excerpt

In the vertebrate eye, the retinal pigment epithelium (RPE) and the neural retina arise from a single layer of neuroectoderm. Factors influencing the differentiation of retinal neurons have been identified; however, little is known about molecules directing the differentiation of the RPE. Here we have found that the neurotrophin brain-derived neurotrophic factor (BDNF) plays an autocrine role in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9348344
PMCID: PMC6573079

Genes

RPE
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Critical role of TrkB and brain-derived neurotrophic factor in the differentiation and survival of retinal pigment epithelium.PMID 9348344Read ↗

A splice variant of trkB and brain-derived neurotrophic factor are co-expressed in retinal pigmented epithelial cells and promote differentiated characteristics.Semantic proximity Read ↗

Role of neurotrophin receptor TrkB in the maturation of rod photoreceptors and establishment of synaptic transmission to the inner retina.Semantic proximity Read ↗

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A, B, C’s of Trk Receptors and Their Ligands in Ocular RepairSemantic proximity Read ↗

Changes in retinal expression of neurotrophins and neurotrophin receptors induced by ocular hypertensionSemantic proximity Read ↗

Dlx2 homeobox gene transcriptional regulation of Trkb neurotrophin receptor expression during mouse retinal development.Semantic proximity Read ↗

The p75 receptor is required for BDNF-induced differentiation of neural precursor cells.Semantic proximity Read ↗

Increased expression of brain-derived neurotrophic factor preserves retinal function and slows cell death from rhodopsin mutation or oxidative damage.Semantic proximity Read ↗

In vitro transdifferentiation of embryonic rat retinal pigment epithelium to neural retina.Semantic proximity Read ↗

In retinitis pigmentosa TrkC.T1-dependent vectorial Erk activity upregulates glial TNF-α, causing selective neuronal death.Semantic proximity Read ↗

Exogenous brain-derived neurotrophic factor (BDNF) reverts phenotypic changes in the retinas of transgenic mice lacking the BDNF gene.Semantic proximity Read ↗

In vitro analysis of a mammalian retinal progenitor that gives rise to neurons and glia.Semantic proximity Read ↗

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