Article
In retinitis pigmentosa TrkC.T1-dependent vectorial Erk activity upregulates glial TNF-α, causing selective neuronal death.
Cell death & disease - 14 Dec 2017
Galán Alba, Jmaeff Sean, Barcelona Pablo F, Brahimi Fouad, Sarunic Marinko V, Saragovi H Uri
Abstract excerpt
In some diseases the TrkC.T1 isoform is upregulated in glia, associated with glial TNF-α production and neuronal death. What remains unknown are the activating signals in glia, and how paracrine signals may be selective for a targeted neuron while sparing other proximate neurons. We studied these questions in the retina, where Müller glia contacts photoreceptors on one side and retinal ganglion cells on the...
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