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Article

Suppression of trkB expression by antisense oligonucleotides alters a neuronal phenotype in the rod pathway of the developing rat retina.

Proceedings of the National Academy of Sciences of the United States of America - 29 Oct 1996

Rickman D W, Bowes Rickman C

Abstract excerpt

trkB is the high-affinity receptor for brain-derived neurotrophic factor (BDNF), a trophic molecule with demonstrated effects on the survival and differentiation of a wide variety of neuronal populations. In the mammalian retina, trkB is localized to both ganglion cells and numerous cells in the...

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Identifiers

PMID: 8901622
DOI: 10.1073/pnas.93.22.12564
PMCID: PMC38032

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-8901622-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Suppression of trkB expression by antisense oligonucleotides alters a neuronal phenotype in the rod pathway of the developing rat retina.PMID 8901622Read ↗

Exogenous brain-derived neurotrophic factor (BDNF) reverts phenotypic changes in the retinas of transgenic mice lacking the BDNF gene.Semantic proximity Read ↗

Critical role of TrkB and brain-derived neurotrophic factor in the differentiation and survival of retinal pigment epithelium.Semantic proximity Read ↗

Role of neurotrophin receptor TrkB in the maturation of rod photoreceptors and establishment of synaptic transmission to the inner retina.Semantic proximity Read ↗

Increased expression of brain-derived neurotrophic factor preserves retinal function and slows cell death from rhodopsin mutation or oxidative damage.Semantic proximity Read ↗

Changes in retinal expression of neurotrophins and neurotrophin receptors induced by ocular hypertensionSemantic proximity Read ↗

TrkB and TrkC signaling are required for maturation and synaptogenesis of hippocampal connections.Semantic proximity Read ↗

Developmental expression of neurotrophin receptor genes in rat geniculate ganglion neurons.Semantic proximity Read ↗

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development.Semantic proximity Read ↗

Neocortical neurons lacking the protein-tyrosine kinase B receptor display abnormal differentiation and process elongation in vitro and in vivo.Semantic proximity Read ↗

Cortical degeneration in the absence of neurotrophin signaling: dendritic retraction and neuronal loss after removal of the receptor TrkB.Semantic proximity Read ↗

Abnormal cerebellar development and foliation in BDNF-/- mice reveals a role for neurotrophins in CNS patterning.Semantic proximity Read ↗

Allele-Specific Inhibition of Rhodopsin With an Antisense Oligonucleotide Slows Photoreceptor Cell Degeneration.Semantic proximity Read ↗

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