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Article

A splice variant of trkB and brain-derived neurotrophic factor are co-expressed in retinal pigmented epithelial cells and promote differentiated characteristics.

Brain research - 13 Apr 1998

Hackett S F, Friedman Z, Freund J, Schoenfeld C, Curtis R, DiStefano P S, Campochiaro P A

Abstract excerpt

There is evidence suggesting reciprocal trophic interactions between photoreceptors and the retinal pigmented epithelium (RPE), but the factors involved have not been identified. In this study, we investigated the hypothesis that one or more known neurotrophic factors act upon the RPE. Cultured human and freshly isolated bovine RPE cells demonstrated saturable specific binding for [125I]labeled BDNF, NT-4/5 and...

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Source

Identifiers

PMID: 9573364
DOI: 10.1016/s0006-8993(97)01440-6

Genes

RPE
BDNF
CNTF
NGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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A splice variant of trkB and brain-derived neurotrophic factor are co-expressed in retinal pigmented epithelial cells and promote differentiated characteristics.PMID 9573364Read ↗

Critical role of TrkB and brain-derived neurotrophic factor in the differentiation and survival of retinal pigment epithelium.Semantic proximity Read ↗

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Role of neurotrophin receptor TrkB in the maturation of rod photoreceptors and establishment of synaptic transmission to the inner retina.Semantic proximity Read ↗

The secreted brain-derived neurotrophic factor precursor pro-BDNF binds to TrkB and p75NTR but not to TrkA or TrkC.Semantic proximity Read ↗

Increased expression of brain-derived neurotrophic factor preserves retinal function and slows cell death from rhodopsin mutation or oxidative damage.Semantic proximity Read ↗

In retinitis pigmentosa TrkC.T1-dependent vectorial Erk activity upregulates glial TNF-α, causing selective neuronal death.Semantic proximity Read ↗

Suppression of trkB expression by antisense oligonucleotides alters a neuronal phenotype in the rod pathway of the developing rat retina.Semantic proximity Read ↗

Functionally antagonistic interactions between the TrkA and p75 neurotrophin receptors regulate sympathetic neuron growth and target innervation.Semantic proximity Read ↗

In vitro transdifferentiation of embryonic rat retinal pigment epithelium to neural retina.Semantic proximity Read ↗

Expression and function of TRK-B and BDNF in human neuroblastomas.Semantic proximity Read ↗

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