Article
A single intracerebroventricular injection of dexamethasone elevates food intake and plasma insulin and depresses metabolic rates in adrenalectomized obese (ob/ob) mice.
The Journal of nutrition - 1 Mar 1995
Chen H L, Romsos D R
Abstract excerpt
A single intracerebroventricular (ICV) injection of dexamethasone rapidly (within 30 min to 3 h) increases plasma insulin and suppresses oxygen consumption in adrenalectomized ob/ob mice with minimal effects in lean mice. Food intake of these adrenalectomized ob/ob mice was unaffected by ICV dexamethasone during these short-term studies. However, in a longer-term study with adrenalectomized gold...
Topics
- Adrenalectomy
- Animals
- Basal Metabolism
- Dexamethasone
- Eating
- Injections, Intraventricular
- Insulin
- Kinetics
- Male
- Mice
- Mice, Obese
- Oxygen Consumption