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Article

The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation.

Cell - 17 Oct 1997

Kowenz-Leutz E, Herr P, Niss K, Leutz A

Abstract excerpt

The homeobox gene GBX2 was identified as a target gene of the v-Myb oncoprotein encoded by the avian myeloblastosis virus (AMV). GBX2 activation by c-Myb requires signal transduction emanating from the cell surface while the leukemogenic AMV v-Myb constitutively induces the GBX2 gene. Mutations in the DNA binding domain of AMV-Myb render it independent of signaling events and concomitantly abrogate the...

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Source

Identifiers

PMID: 9346236
DOI: 10.1016/s0092-8674(00)80401-8

Genes

GBX2
EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation.PMID 9346236Read ↗

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