Article
The leucine zipper region of Myb oncoprotein regulates the commitment of hematopoietic progenitors.
Blood - 15 Dec 2001
Karafiát V, Dvoráková M, Pajer P, Králová J, Horejsí Z, Cermák V, Bartůnek P, Zenke M, Dvorák M
Abstract excerpt
The development of blood cells proceeds from pluripotent stem cells through multipotent progenitors into mature elements belonging to at least 8 different lineages. The lineage choice process during which stem cells and progenitors commit to a particular lineage is regulated by a coordinated action of extracellular signals and transcription factors. Molecular mechanisms controlling commitment are largely unknown....
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