Article
HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo.
Blood - 15 Feb 2005
Fischbach Neal A, Rozenfeld Sofia, Shen Weifang, Fong Stephen, Chrobak Daniel, Ginzinger David, Kogan Scott C, Radhakrishnan Archana, Le Beau Michelle M, Largman Corey, Lawrence H Jeffrey
Abstract excerpt
The HOX family of homeobox genes plays an important role in normal and malignant hematopoiesis. Dysregulated HOX gene expression profoundly effects the proliferation and differentiation of hematopoietic stem cells (HSCs) and committed progenitors, and aberrant activation of HOX genes is a common...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.