Article
A hybrid between a resistant and a susceptible strain of mouse alters the pattern of Theiler's murine encephalomyelitis virus-induced white matter disease and favors oligodendrocyte-mediated remyelination.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Jun 1995
Dal Canto M C, Melvold R W, Kim B S
Abstract excerpt
Theiler's murine encephalomyelitis virus (TMEV) produces a chronic disease in its natural host, the mouse, characterised by primary inflammatory demyelination of the spinal cord. This viral infection is considered a very good model for human MS because the pathogenesis of myelin injury is mediate...
Topics
- Animals
- Brain Diseases
- Demyelinating Diseases
- Disease Models, Animal
- Disease Susceptibility
- Genetic Predisposition to Disease
- Hybridization, Genetic
- Immunity, Innate
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Myelin Sheath
- Oligodendroglia
- Poliomyelitis
- Spinal Cord
- Theilovirus