Article
Treatment with bacterial LPS renders genetically resistant C57BL/6 mice susceptible to Theiler's virus-induced demyelinating disease.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 1995
Pullen L C, Park S H, Miller S D, Dal Canto M C, Kim B S
Abstract excerpt
Theiler's murine encephalomyelitis virus (TMEV) induces a demyelinating disease in susceptible strains, which clinically and histopathologically resembles human multiple sclerosis. Since bacterial LPS produced by Gram-negative bacteria is known to potentiate an immune response and trigger resident central nervous system cells to produce various inflammatory cytokines, we examined the ability of LPS to affect...
Topics
- Adjuvants, Immunologic
- Animals
- Demyelinating Diseases
- Disease Susceptibility
- Genetic Predisposition to Disease
- Hypersensitivity, Delayed
- Injections, Intraperitoneal
- Interleukin-1
- Lipopolysaccharides
- Lymphocyte Activation