Article
PCR typing of two short tandem repeat (STR) structures upstreams of the human myelin basic protein (MBP) gene; the genetic susceptibility in multiple sclerosis and monosymptomatic idiopathic optic neuritis in Danes.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Nov 1995
Nellemann L J, Frederiksen J, Morling N
Abstract excerpt
We investigated two short tandem tetranucleotide (TGGA) repeat polymorphisms upstreams of the myelin basic protein (MBP) gene. The region was amplified by the polymerase chain reaction (PCR) and the two repeat systems were separated by cutting with the restriction enzyme NlaIII. The lengths of th...
Topics
- Alleles
- Chromosome Deletion
- Cloning, Molecular
- DNA
- Denmark
- Gene Frequency
- Genes
- Genetic Predisposition to Disease
- Humans
- Microsatellite Repeats
- Multiple Sclerosis
- Myelin Basic Protein
- Optic Neuritis
- Polymerase Chain Reaction