Article
Genetic variability in the extracellular matrix protein as a determinant of risk for developing HTLV-I-associated neurological disease.
Immunogenetics - 1 Jan 2006
Nobuhara Yasuyuki, Usuku Koichiro, Saito Mineki, Izumo Shuji, Arimura Kimiyoshi, Bangham Charles R M, Osame Mitsuhiro
Abstract excerpt
Aggrecan, which is a well-known proteoglycan in joint cartilage, also exists in the spinal cord and plays an important role in maintaining water content in the extracellular matrix structure. In this study, we first examined the variable number of tandem repeat (VNTR) polymorphism of the aggrecan gene in 227 HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients, in 217 HTLV-I-infected...
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