Article
Linkage disequilibrium between the MBP tetranucleotide repeat and multiple sclerosis is restricted to a geographically defined subpopulation in Finland.
Genes and immunity - 1 Mar 2003
Pihlaja H, Rantamäki T, Wikström J, Sumelahti M-L, Laaksonen M, Ilonen J, Ruutiainen J, Pirttilä T, Elovaara I, Reunanen M, Kuokkanen S, Peltonen L, Koivisto K, Tienari P J
Abstract excerpt
We have previously found evidence for linkage as well as allelic and haplotype association between the myelin basic protein (MBP) gene and multiple sclerosis (MS). These findings have, however, not been reproduced in other populations. Here, we have analyzed association between MBP and MS in a new set of 349 Finnish triad families. Families with a parent born in the Southern Ostrobothnian region in western...
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