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Article

Role of cyclins in neuronal differentiation of immortalized hippocampal cells.

Molecular and cellular biology - 1 Nov 1997

Xiong W, Pestell R, Rosner M R

Abstract excerpt

The proto-oncogene cyclin D1 and the neuron-specific cyclins p35 and p39 are expressed during brain maturation. To investigate the role of these cyclins in neuronal differentiation, we used a conditionally immortalized rat hippocampal cell line, H19-7, that expresses cyclin-dependent kinases 4 and 5 (cdk4 and -5). Cyclin D1, which activates cdk4 and binds but does not activate cdk5, was increased upon...

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Identifiers

PMID: 9343422
DOI: 10.1128/MCB.17.11.6585
PMCID: PMC232512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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