Article
Phosphorylation of p27Kip1 at Thr187 by cyclin-dependent kinase 5 modulates neural stem cell differentiation.
Molecular biology of the cell - 15 Oct 2010
Zheng Ya-Li, Li Bing-Sheng, Rudrabhatla Parvathi, Shukla Varsha, Amin Niranjana D, Maric Dragan, Kesavapany Sashi, Kanungo Jyotshnabala, Pareek Tej K, Takahashi Satoru, Grant Philip, Kulkarni Ashok B, Pant Harish C
Abstract excerpt
Cyclin-dependent kinase 5 (Cdk5) plays a key role in the development of the mammalian nervous system; it phosphorylates a number of targeted proteins involved in neuronal migration during development to synaptic activity in the mature nervous system. Its role in the initial stages of neuronal commitment and differentiation of neural stem cells (NSCs), however, is poorly understood. In this study, we show that...
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