Article
The mutagenic potential of a single DNA double-strand break in a mammalian chromosome is not influenced by transcription.
DNA repair - 7 Oct 2003
Allen Chris, Miller Cheryl A, Nickoloff Jac A
Abstract excerpt
In eukaryotes, DNA double-strand breaks (DSBs) are repaired by competing HR and non-homologous end-joining (NHEJ) pathways. DSB repair by HR is highly accurate, while NHEJ can result in deletions and insertions. Transcription enhances certain DNA repair pathways and spontaneous homologous recombination (HR). As a means to promote accurate repair in active genes, we thought it possible that the balance between HR...
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