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Article

Transcription of a donor enhances its use during double-strand break-induced gene conversion in human cells.

Molecular and cellular biology - 1 Apr 2006

Schildkraut Ezra, Miller Cheryl A, Nickoloff Jac A

Abstract excerpt

Homologous recombination (HR) mediates accurate repair of double-strand breaks (DSBs) but carries the risk of large-scale genetic change, including loss of heterozygosity, deletions, inversions, and translocations. Nearly one-third of the human genome consists of repetitive sequences, and DSB repair by HR often requires choices among several homologous repair templates, including homologous chromosomes, sister...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16581784
DOI: 10.1128/MCB.26.8.3098-3105.2006
PMCID: PMC1446947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transcription of a donor enhances its use during double-strand break-induced gene conversion in human cells.PMID 16581784Read ↗

Transcriptional effects on double-strand break-induced gene conversion tracts.Semantic proximity Read ↗

Chromosomal double-strand breaks induce gene conversion at high frequency in mammalian cells.Semantic proximity Read ↗

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Preferential repair of UV damage in highly transcribed DNA diminishes UV-induced intrachromosomal recombination in mammalian cells.Semantic proximity Read ↗

Gene conversion tracts in Saccharomyces cerevisiae can be extremely short and highly directional.Semantic proximity Read ↗

Transcription enhances intrachromosomal homologous recombination in mammalian cells.Semantic proximity Read ↗

Increased transcription decreases the spontaneous mutation rate at the thymidine kinase locus in human cells.Semantic proximity Read ↗

Effects of mismatch repair and Hpr1 on transcription-stimulated mitotic recombination in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Interchromosomal gene conversion at an endogenous human cell locus.Semantic proximity Read ↗

Defects in RNase H2 Stimulate DNA Break Repair by RNA Reverse Transcribed into cDNA.Semantic proximity Read ↗

Gene-conversion tract directionality is influenced by the chromosome environment.Semantic proximity Read ↗

Transcription stimulates homologous recombination in mammalian cells.Semantic proximity Read ↗

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